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The disease filariasis, commonly known as elephantiasis, is caused by a(n)


A) ectoparasite.
B) endoparasite.
C) insect.
D) bacterium.
E) fungus.

F) B) and C)
G) A) and B)

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The term used to designate how many bacteria or viruses are required to kill 50% of an experimental group of hosts is


A) ID50.
B) LD50.
C) pathogenicity.
D) infectivity.
E) virulence.

F) All of the above
G) A) and B)

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Diphtheria toxin is a classic AB exotoxin. How does it cause host cell damage?

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Diphtheria toxin is an AB toxin whose re...

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Pathogenicity islands include all of the following EXCEPT that


A) genes are not expressed as operons.
B) GC/AT ratio differs from the rest of the genome.
C) residual phage genomes flank the island.
D) they are often linked to tRNA.
E) they encode the type III protein secretion (T3SS) export systems.

F) C) and E)
G) B) and C)

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What characteristics of a pathogen distinguish it from a commensal, in terms of its ability to infect and replicate within a eukaryotic host?

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Commensals are essentially relegated to ...

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Microbes can be transmitted indirectly from one person to another by inanimate objects, collectively called fomites. Describe the role of fomites in the spread of influenza.

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The influenza virus can be spread by aer...

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An example of vertical transmission of infectious agents is


A) Staphylococcus spp. gaining antibiotic resistance genes through conjugation.
B) HIV passing from mother to child in utero.
C) an infectious ameba obtained from a water sample.
D) influenza being passed by a sneeze.
E) hepatitis being transmitted by an infected needle stick.

F) None of the above
G) A) and B)

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Type I and Type IV pili both


A) are similar in mode of secretion.
B) are mannose resistant.
C) have an assembly that does not involve the secA general secretory pathway.
D) are encoded by a pathogenicity island.
E) are exclusively used for pathogenesis.

F) C) and D)
G) B) and C)

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Tropheryma whipplei is the causative agent for Whipple's disease. It could not be cultured until recently, when the genomic data showed that it


A) was auxotrophic for some amino acids.
B) was an obligate intracellular pathogen.
C) needed a helper virus to grow.
D) needed high levels of iron.
E) is a virus that needs cell culture.

F) A) and E)
G) B) and E)

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Describe what is happening at step 1 in the figure below. Describe what is happening at step 1 in the figure below.

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There is a fusion be...

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